Severe familial hypercholesterolaemia: Current and future management
نویسندگان
چکیده
منابع مشابه
High-dose atorvastatin therapy in severe heterozygous familial hypercholesterolaemia.
Lipid targets can be difficult to attain in familial hypercholesterolaemia. To compare atorvastatin with simvastatin-fenofibrate and simvastatin-cholestyramine therapy, we studied 54 patients with familial hypercholesterolaemia over periods of 2-6 months on each therapeutic regimen. The atorvastatin regimen reduced total cholesterol by 41.2 +/- 11.2%, LDL by 45.6 +/- 15.5%, triglycerides by 33....
متن کاملGuidelines for the diagnosis and management of familial hypercholesterolaemia.
Familial hypercholesterolaemia (FH) is a dominantly inherited condition that is due to a genetic defect in one of several genes that affect receptor-mediated uptake of low density lipoprotein (LDL) (see “Molecular Genetics” below). Affected individuals suffer metabolic and clinical features (Table 1) that include impaired uptake of plasma LDL cholesterol, resulting in high cholesterol levels an...
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متن کاملFamilial hypercholesterolaemia: underdiagnosed and undertreated.
Autosomal dominant familial hypercholesterolaemia (FH) is the most common inherited disorder known to cause premature coronary heart disease in people of European descent. The estimated prevalence of FH is 1 in 500, and heterozygous FH carries a high risk of premature coronary disease if left untreated (.50% risk in men by the age of 50 and .30% in women by 60 years). However, the condition is ...
متن کاملFamilial hypercholesterolaemia in Portugal.
Familial hypercholesterolaemia (FH) is characterised clinically by an increased level of circulating LDL cholesterol that leads to lipid accumulation in tendons and arteries, premature atherosclerosis and increased risk of coronary heart disease (CHD). Although Portugal should have about 20,000 cases, this disease is severely under-diagnosed in our country, this being the first presentation of ...
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ژورنال
عنوان ژورنال: Archives of Cardiovascular Diseases
سال: 2012
ISSN: 1875-2136
DOI: 10.1016/j.acvd.2012.05.011